CAUSES OF MDDDepression doesn't usually stem from a single cause. Instead, it's often the result of a mix of factors that can vary from person to person, sometimes even without an obvious trigger. According to the current scientific medical model, both environmental and biological factors contribute to all mental health disorders. Brain chemistry and regulation issues are part of the picture, but not the full story. Things like loneliness, financial hardship, poor housing or experiencing discrimination also contribute.Possible contributing factors include:
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Childhood experiences. Difficult events like abuse, neglect, or loss can increase vulnerability later in life.
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Life events. Things like bereavement, job loss, money worries, relationship problems, or big life changes can be triggering, especially when combined with low support.
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Styles of thinking. Negative patterns, like self-blame or repetitive worrying, can boost the risk of depression too.
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Other mental health issues. Conditions like anxiety often coexist and can worsen depression. For instance, Post traumatic stress disorder contains depressive symptoms itself.
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Physical health problems. Chronic or serious illnesses (e.g., heart disease, thyroid issues, chronic pain) increase the likelihood of depression.
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Family history and genetics. A family history of depression raises the risk, with genetics accounting for about 40% of the risk.
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Medications. Some drugs (like beta-blockers, interferon, isotretinoin or hormonal treatments, ets.) can have depression as a side effect.
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Recreational drugs and alcohol. Substance use, especially long-term, can both trigger and worsen depression.
⭑ Sleep, diet and exercise. Lack of sleep, poor nutrition, and inactivity disrupt mood regulation.
ANTIDEPRESSANTS FOR MDDIf you’ve tried other treatments but they haven’t helped, for moderate and severe depression, or depression accompanied by anxiety, PSTD and other mental disorders, or depression with intense feelings of self guilt, worthless, suicidal thoughts or behavior antidepressants are essential according to
NICE guidelines. Antidepressants also most helpfulIf, if you’ve tried lifestyle or therapy approaches without success, when physical symptoms (pain, sleep problems) are severe and if you have had repeated episodes or a strong family history of depression.
If you don't have bipolar disorder, you will benefit from any type of antidepressants. The most popular group is
selective serotonin reuptake inhibitors (SSRIs) and serotonin and
norepinephrine reuptake inhibitors (SNRIs). In the European Union they can be prescribed by a psychiatrist or even your GP. They might offer medication as a treatment on its own. Or they might recommend taking medication as well as having talking therapy, do aerobic exercises (biking, swimming, running, ets.) or sunbathing or use 10 000 lumen lamps.
In some cases, your doctor may also prescribe
aripiprazole or
lithium alongside antidepressants. This is most likely if you have severe depression, or your depression keeps coming back. And it is usually when you have tried two types of antidepressants on their own at maximum bearable dosage and they aren't working.
MDD TREATMENT DURATIONSome people find an antidepressants helps right away, while others may need to try a few different options before finding what works best. You can talk to your doctor about the choices available and what might suit you.
NICE guidelines recommend that you keep taking antidepressants for at least 6 months after an episode of depression ends. Some people following the advice of the psychiatrist may choose to stay on medication longer-term, especially if they've experienced multiple episodes of depression in the past. In these cases, continuing medication can help reduce the risk of future relapses.
ANTIDEPRESSANTS DISCONTINUATIONIf you’re taking medication for depression, it’s important not to stop it suddenly. Stopping abruptly can lead to withdrawal symptoms that may be difficult to manage—and with some antidepressants, it can even be dangerous. If you’re thinking about coming off your medication:
⭑ Talk to the healthcare professional who prescribed it.
⭑ Come off gradually, over time, with medical guidance.
⭑ Understand the possible risks and how to reduce them safely.
Cooperating with your doctor ensures the process is as safe and comfortable as possible.